Research Strategy

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Applied
Neuroscience

Our Research Strategy
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Applied Neuroscience

Electrophysiology, Neurochemistry & Pharmacology within the same brain region
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For a representative application of this multidisciplinary strategy, see:
Urenjak J, Obrenovitch TP (2000) Kynurenine-3-hydroxylase inhibition in rats: effects on extracellular kynurenic acid concentration and N-methyl-D-aspartate-induced depolarisation in the striatum. J Neurochem 75: 2427-2433.

This research strategy is applicable to mice with targeted mutations. For example, see:
Shimizu-Sasamata M, Bosque-Hamilton P, Huang PL, Moskowitz MA, Lo EH (1998) Attenuated neurotransmitter release and spreading depression-like depolarizations after focal ischemia in mutant mice with disrupted type I nitric oxide synthase gene. J Neurosci 18:9564-9571.

A separate microcannula may be used for accurate application of
high molecular weight compounds in the region under study